منابع مشابه
Understanding the Pathogenesis of Zika Virus Infection Using Animal Models
Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental ...
متن کاملAnimal Models of Zika Virus Infection, Pathogenesis, and Immunity.
Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and in...
متن کاملThe Development of Small Animal Models for Zika Virus Vaccine Efficacy Testing and Pathological Assessment
Zika virus (ZIKV) is a mosquito-borne flavivirus serologically grouped within the family Flaviviridae, which was initially isolated from a febrile sentinel monkey in the Zika Forest of Uganda in 1947. Subsequent genetic analyses have demonstrated the presence of two distinctive African and Asian viral genotypes. After years of being associated only with sporadic human illness, the first outbrea...
متن کاملPotential small animal models for virus-induced chronic respiratory disease.
Although several clinical studies have suggested that some of the acute exacerbations of chronic bronchitis may be produced by certain viruses, the precise role of these agents in the pathogenesis of progressive chronic respiratory disease has not yet been defined.`8 The prolonged and complex natural history of chronic respiratory disease in man has made it extremely difficult to assess the rol...
متن کاملZika Virus: A New Animal Model for an Arbovirus
In the latest issue of PLOS Neglected Tropical Diseases [1], Dowall and colleagues describe a novel small animal model for Zika virus infection. Along with two other reports in the recent weeks [2,3], this collection of papers marks an important turning point in Zika virus research and enables in vivo testing and evaluation of candidate vaccines and therapeutics. The authors show that type-1 in...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2017
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jix465